Gait analysis in patients with Parkinson's disease and motor fluctuations: Influence of levodopa and comparison with other measures of motor function
Identifieur interne : 001E96 ( Main/Exploration ); précédent : 001E95; suivant : 001E97Gait analysis in patients with Parkinson's disease and motor fluctuations: Influence of levodopa and comparison with other measures of motor function
Auteurs : John D. O'Sullivan [Australie] ; Catherine M. Said [Australie] ; Louise C. Dillon [Australie] ; Marion Hoffman [Australie] ; Hughes [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 1998-11.
English descriptors
- KwdEn :
Abstract
Although clinical rating scales and simple timed tests of motor function are widely used to assess motor response to therapy, gait analysis may provide an alternative measure of this response. We studied 15 patients with PD complicated by motor fluctuations, first to determine changes in temporal and spatial gait parameters following levodopa, secondly to assess the stability of repeated gait measures and timed tests in “off” and “on” states, and thirdly to determine the use of gait analysis in the assessment of the dopaminergic response. Gait analysis (velocity, stride length, cadence, and double limb support), clinical rating scales (modified Webster scale and Hoehn and Yahr stage), and timed tests of motor function (hand tapping and stand‐walk‐sit time) were performed before (“off”) and after (“on”) a levodopa challenge. Stride length and gait velocity increased following medication whereas cadence and double limb support did not. Most gait measures and the stand‐walk‐sit time were stable over three consecutive trials in both “off” and “on” states. Of the gait measures, only cadence in the “off” state changed significantly whereas the tapping count improved with repeated trials in both “off” and “on” states. Changes in stride length, gait velocity, and tapping count following levodopa correlated with changes in clinical rating scales following treatment. Measurement of gait parameters provides a reliable, objective alternative to rating scales and timed tests in assessing the dopaminergic response in patients with PD and motor fluctuations.
Url:
DOI: 10.1002/mds.870130607
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gait analysis in patients with Parkinson's disease and motor fluctuations: Influence of levodopa and comparison with other measures of motor function</title><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name></author><author><name sortKey="Said, Catherine M" sort="Said, Catherine M" uniqKey="Said C" first="Catherine M." last="Said">Catherine M. Said</name></author><author><name sortKey="Dillon, Louise C" sort="Dillon, Louise C" uniqKey="Dillon L" first="Louise C." last="Dillon">Louise C. Dillon</name></author><author><name sortKey="Hoffman, Marion" sort="Hoffman, Marion" uniqKey="Hoffman M" first="Marion" last="Hoffman">Marion Hoffman</name></author><author><name sortKey="Hughes" sort="Hughes" uniqKey="Hughes" last="Hughes">Hughes</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5EEE719A7B3ADE82049130DB322DB8F6D3357346</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1002/mds.870130607</idno><idno type="url">https://api.istex.fr/document/5EEE719A7B3ADE82049130DB322DB8F6D3357346/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001912</idno><idno type="wicri:Area/Main/Curation">001664</idno><idno type="wicri:Area/Main/Exploration">001E96</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Gait analysis in patients with Parkinson's disease and motor fluctuations: Influence of levodopa and comparison with other measures of motor function</title><author><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Departments Of Neurology, Austin & Repatriation Medical Centre, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Said, Catherine M" sort="Said, Catherine M" uniqKey="Said C" first="Catherine M." last="Said">Catherine M. Said</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Departments Of Physiotherapy, Austin & Repatriation Medical Centre, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Dillon, Louise C" sort="Dillon, Louise C" uniqKey="Dillon L" first="Louise C." last="Dillon">Louise C. Dillon</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Departments Of Aged Care Services, Austin & Repatriation Medical Centre, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Hoffman, Marion" sort="Hoffman, Marion" uniqKey="Hoffman M" first="Marion" last="Hoffman">Marion Hoffman</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Departments Of Neurology, Austin & Repatriation Medical Centre, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Hughes" sort="Hughes" uniqKey="Hughes" last="Hughes">Hughes</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Departments Of Neurology, Austin & Repatriation Medical Centre, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Departments Of Aged Care Services, Austin & Repatriation Medical Centre, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1998-11">1998-11</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="900">900</biblScope><biblScope unit="page" to="906">906</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5EEE719A7B3ADE82049130DB322DB8F6D3357346</idno><idno type="DOI">10.1002/mds.870130607</idno><idno type="ArticleID">MDS870130607</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gait</term><term>Levodopa</term><term>Motor fluctuations</term><term>Parkinson's disease</term><term>Rating scales</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although clinical rating scales and simple timed tests of motor function are widely used to assess motor response to therapy, gait analysis may provide an alternative measure of this response. We studied 15 patients with PD complicated by motor fluctuations, first to determine changes in temporal and spatial gait parameters following levodopa, secondly to assess the stability of repeated gait measures and timed tests in “off” and “on” states, and thirdly to determine the use of gait analysis in the assessment of the dopaminergic response. Gait analysis (velocity, stride length, cadence, and double limb support), clinical rating scales (modified Webster scale and Hoehn and Yahr stage), and timed tests of motor function (hand tapping and stand‐walk‐sit time) were performed before (“off”) and after (“on”) a levodopa challenge. Stride length and gait velocity increased following medication whereas cadence and double limb support did not. Most gait measures and the stand‐walk‐sit time were stable over three consecutive trials in both “off” and “on” states. Of the gait measures, only cadence in the “off” state changed significantly whereas the tapping count improved with repeated trials in both “off” and “on” states. Changes in stride length, gait velocity, and tapping count following levodopa correlated with changes in clinical rating scales following treatment. Measurement of gait parameters provides a reliable, objective alternative to rating scales and timed tests in assessing the dopaminergic response in patients with PD and motor fluctuations.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="O Sullivan, John D" sort="O Sullivan, John D" uniqKey="O Sullivan J" first="John D." last="O'Sullivan">John D. O'Sullivan</name></noRegion><name sortKey="Dillon, Louise C" sort="Dillon, Louise C" uniqKey="Dillon L" first="Louise C." last="Dillon">Louise C. Dillon</name><name sortKey="Hoffman, Marion" sort="Hoffman, Marion" uniqKey="Hoffman M" first="Marion" last="Hoffman">Marion Hoffman</name><name sortKey="Hughes" sort="Hughes" uniqKey="Hughes" last="Hughes">Hughes</name><name sortKey="Hughes" sort="Hughes" uniqKey="Hughes" last="Hughes">Hughes</name><name sortKey="Said, Catherine M" sort="Said, Catherine M" uniqKey="Said C" first="Catherine M." last="Said">Catherine M. Said</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E96 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E96 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:5EEE719A7B3ADE82049130DB322DB8F6D3357346
|texte= Gait analysis in patients with Parkinson's disease and motor fluctuations: Influence of levodopa and comparison with other measures of motor function
}}
| This area was generated with Dilib version V0.6.23. |  |